Reference: The 2018-2019 Watson Lecture Series, Caltech, Beckman Auditorium
World’s Deepest-Penetration and Fastest Optical Cameras
by Lihong Wang
Wednesday, November 28, 2018, 8:00 PM – 9:30 PM
Lihong Wang will discuss the development of photoacoustic tomography, which allows scientists to peer deep into biological tissue. He will also talk about his lab’s development of compressed ultrafast photography that records 10 trillion frames per second.
I came across some articles recently that ultrafast photography reached a point where a light pulse can be imaged. I was interested because in the past claims were made that atomic events — like photon emission — were instantaneous or essentially so because such events were too fast to ever image. Well, that may change. And there are signs that “quantum leaps” do indeed take a slice of time (so there is some physical process in space-time).
These demonstrations, like in most entanglement correlation experiments, are post hoc visualizations of assumed identical events repeated trillions of times.
YouTube: “Lihong Wang: World’s fastest camera for ultrafast phenomena provides temporal information” (published March 20, 2017). Photonic version of Mach cone — using laser light to image light propagating in a background medium.
[From transcript, somewhat reconstructed.] If we have a background medium of some sort, the speed of light will be reduced in that medium relative to the speed of light in vacuum. We created a tunnel where the speed of light in that tunnel is greater than the speed of light in a medium. We propagate a light pulse — a very short light pulse — in that medium … [which] scatters within the tunnel [and] generates secondary light sources and those light sources will be propagated in the background medium; so, the light source will propagate at a greater speed and that creates a superluminal light source.
YouTube: TED “Imaging at a trillion frames per second | Ramesh Raskar” (published on Jul 26, 2012).
Ramesh Raskar presents femto-photography, a new type of imaging so fast it visualizes the world one trillion frames per second, so detailed it shows light itself in motion. This technology may someday be used to build cameras that can look “around” corners or see inside the body without X-rays.
[Selected comments to clarify context of what was presented.]
1. Who … was his audience? These people just saw the speed of light, the fastest speed there is in our world. And they saw it slowed down enough to see it move in SLOW MOTION! Do they not understand what they just saw? The audience at the iPhone 5 [event] was more excited than these people. This is easily one of the most incredible advances in science! The ability to see the speed of light… it’s pretty … awesome people, get hype!
2. They aren’t really taking a video of a single event. They are repeating the event a trillion times and taking frames at different instances in time to get one full event. So if you think you can use this as a slow-mo camera to capture a water balloon bursting, you better have a LOT of water balloons …
3. I think some of you may be a little bit misled by this video. You are not seeing a particular beam of light move through a particular bottle in a single event. You are seeing the motion of light of that particular circumstance.
4. It took thousands of measurements over several minutes, hours, or days to compile that short clip. Never the less, the clip does show the movement of light and it is backed by data.
One picosecond is equal to 1000 femtoseconds, or 1/1000 nanoseconds. Because the next SI unit is 1000 times larger, measurements of 10−11 and 10−10 second are typically expressed as tens or hundreds of picoseconds. Some notable measurements in this range include:
- 1 picosecond – time taken by light in a vacuum to travel approximately 0.30 mm
- 1 picosecond – half-life of a bottom quark
- picoseconds to nanoseconds – phenomena observable by dielectric spectroscopy
- 1.2 picoseconds – switching time of the world’s fastest transistor (845 GHz, as of 2006)
- 3.3 picoseconds (approximately) – time taken for light to travel 1 millimeter
Chirped pulse amplification (CPA) is a technique for amplifying an ultrashort laser pulse up to the petawatt level with the laser pulse being stretched out temporally and spectrally prior to amplification [thereby avoiding problematical nonlinear effects impacting the beam or laser’s components].
Chirped-pulse amplification was originally invented as a technique to increase the available power in radar in 1960. CPA for lasers was introduced by Gérard Mourou and Donna Strickland at the University of Rochester in the mid 1980s, a work for which they received the Nobel Prize in Physics in 2018.
In CPA … an ultrashort laser pulse is stretched out in time prior to introducing it to the gain medium using a pair of gratings that are arranged so that the low-frequency component of the laser pulse travels a shorter path than the high-frequency component does. After going through the grating pair, the laser pulse becomes positively chirped, that is, the high-frequency component lags behind the low-frequency component, and has longer pulse duration than the original by a factor of 1000 to 100000.
Then the stretched pulse, whose intensity is sufficiently low compared with the intensity limit of gigawatts per square centimeter, is safely introduced to the gain medium and amplified by a factor of a million or more. Finally, the amplified laser pulse is recompressed back to the original pulse width through the reversal process of stretching, achieving orders of magnitude higher peak power than laser systems could generate before the invention of CPA.
In addition to the higher peak power, CPA makes it possible to miniaturize laser systems (the compressor being the biggest part). A compact high-power laser, known as a tabletop terawatt laser (T3 laser), can be created based on the CPA technique.
Phys.org (October 2, 2018): First experiments at new X-ray laser reveal unknown structure of antibiotics killer
An international collaboration led by DESY and consisting of over 120 researchers has announced the results of the first scientific experiments at Europe’s new X-ray laser, European XFEL.
The 3.4 kilometres long European XFEL is designed to deliver X-ray flashes every 0.000,000,220 seconds (220 nanoseconds). To unravel the three-dimensional structure of a biomolecule, such as an enzyme, the pulses are used to obtain flash X-ray exposures of tiny crystals grown from that biomolecule. Each exposure gives rise to a characteristic diffraction pattern on the detector. If enough such patterns are recorded from all sides of a crystal, the spatial structure of the biomolecule can be calculated. The structure of a biomolecule can reveal much about how it works.
… every crystal can only be X-rayed once since it is vaporised by the intense flash (after it has produced a diffraction pattern). So, to build up the full three-dimensional structure of the biomolecule, a new crystal has to be delivered into the beam in time for the next flash, by spraying it across the path of the laser in a water jet. Nobody has tried to X-ray samples to atomic resolution at this fast rate before. … To probe biomolecules at full speed, not only the crystals must be replenished fast enough—the water jet is also vaporised by the X-rays and has to recover in time.
To record X-ray diffraction patterns at this fast rate, an international consortium led by DESY scientist Heinz Graafsma designed and built one of the world’s fastest X-ray cameras, tailor-made for the European XFEL. The Adaptive Gain Integrating Pixel Detector (AGIPD) can not only record images as fast as the X-ray pulses arrive, it can also tune the sensitivity of every pixel individually, making the most of the delicate diffraction patterns in which the information on the structure of the sample is encoded.
” … Experiments that used to take hours can now be done in a few minutes, …”
Serial femtosecond X-ray crystallography (SFX) is a powerful method to determine the atomic structure of a sample, typically a biomolecule like a protein. It builds on classic crystallography, which was developed more than a century ago. … The brief, but extremely bright flashes of X-ray lasers like the European XFEL overcome two problems at the same time: They are bright enough to produce usable diffraction patterns even from the smallest crystals, and they are short enough to outrun the radiation damage of the crystals. A typical X-ray laser flash lasts only a few femtoseconds (quadrillionths of a second) and has left the crystal before it is vaporised. This “diffraction before destruction” method produces high-quality diffraction pattern even from tiny crystals. But as every crystal is vaporised in a single flash, a new crystal has to be X-rayed with every flash. Therefore, the scientists spray thousands of randomly oriented protein crystals into the path of the X-ray laser and record series of diffraction patterns until they have gathered enough data to calculate the protein’s structure with atomic resolution.
- So, in femto-photography, how many photons are in a laser pulse 1 millimeter (mm) in length, that is, in a 3.3 picosecond pulse?